We possess the reactors of 60LSUS and 1000LGL for the range of extra-low temperature. Since each reactor has the cooling system by jacket, there is no worry about contamination. The 1000LGL reactor is multi-plant type dealing with inner temperature from -80℃ to 130℃. In addition, we possess a flow reactor which can perform safer and more characteristical reaction, with which we have succeeded in performing a reaction at extra-low temperature safely and mildly.