Curevelist
Pharmaceutical & Cosmetic products
Curevelist is an amphoteric ion polymer with an amino group and carboxyl group in the side chain. It adsorbs to the surface of the damaged stratum corneum and shows a focused moisturizing effect.
- Amino acid derivatives with high biological affinity
- It is expected to have a selective adsorption action on damaged sites and has a significant advantage of maintaining effects in prevention of decline in barrier function for a long time.
- Due to its strong adsorptive property, it does not easily come off from the stratum corneum even in the presence of sebum and sweat or when washed, etc.
- It is expected to be an excellent cosmetic material because it is highly hygroscopic and moisturizing and has a moisture transpiration suppressive action.
| Product name (abbreviation) | Curevelist |
|---|---|
| Display name | Polymethacryloyl Lysine |
| INCI (International Cosmetic Ingredient name) | Polymethacryloyl Lysine |
| Chinese INCI | 聚甲基丙烯酰基赖氨酸 |
Adsorption to damaged stratum corneum
Curevelist, which is an amphoteric ion, adsorbs more to the stratum corneum with various damages compared to various polymer type moisturizers.
Hygroscopicity/water retention
The hygroscopicity of Curevelist is equivalent to that of hyaluronic acid and 1,3-BG, and the water retention is superior to that of 1,3-BG and hyaluronic acid, etc.
Skin barrier function
In SDS damage models, it was confirmed that this product suppressed an increase of transepidermal water loss (TEWL) of rough skin, increased the stratum corneum cell area, and improved the skin condition.
Effectiveness evaluation (human test)
* A lotion containing 1% of Curevelist was used for 1 month. TEWL values in the cheek and changes in the cell area in the stratum corneum before and after use are shown.
Efficacy for hair
The residual amount of each polymer was high for damaged treated hair, and among them, Curevelist showed a high residual rate.
In SEM photographic observation, the surface condition was homogenized after treatment with Curevelist, and high effects as a hair-protecting (repairing) agent were observed.
Hair persistence test
SEM photograph after Curevelist treatment
Physical characteristics
| Appearance | White powder |
|---|---|
| Solubilities | water : soluble. Acetone,methanol : practically insoluble, or insoluble. |
| Storage condition | Room temperature |
Packaging
- 1kg、10kg
Related laws and regulations
| TSCA | Not Listed |
|---|---|
| EINECS | Not Listed |
| REACH | Not Listed |
| Safety data |
Single-dose toxicity test: Negative Skin sensitization test: Negative Primary skin irritation test: Negative Eye irritation test: Negative Continuous skin irritation test: Negative Mutagenicity test: Negative Human patch: Negative Phototoxicity and photosensitization tests are not performed because it is not absorbable. |
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